MTHFR Testing Near You

MTHFR, or methylenetetrahydrofolate reductase, is an enzyme that is involved with a chemical reaction in the body that leads to the production of 5-methyltetrahydrofolate. 5-methyltetrahydrofolate, also known as levomefolic acid, is important to help clear the body of an amino acid known as homocysteine. At high levels, homocysteine can be poisonous to the body and, without the help of the MTHFR enzyme's activity, homocysteine will accumulate.

The MTHFR gene is found on chromosome 1 in humans. Two of the most important SNPs (single nucleotide polymorphisms) in MTHFR are C677T and A1298C. Said another way, the 677 position in MTHFR can have a cytosine (C) or a thymine (T) variant while the 1298 position can have an adenine (A) or a cytosine (C) variant. Approximately 10% of the North American population has the 677TT genotype which is associated with lower MTHFR enzyme activity due to heightened enzyme heat sensitivity. Additionally, people with the 677TT MTHFR genotype are more sensitive to folic acid intake and can have high plasma homocysteine levels in the setting of low dietary folate.

This MTHFR blood test checks for genetic mutations in the C677T and A1298C positions of the methylenetetrahydrofolate reductase gene. To get an MTHFR test at a Quest Diagnostics lab near you, click the button above, complete the medical information questionnaire, select a lab and pay for your blood test. Once your MTHFR lab request is submitted, Push Health will immediately contact licensed medical providers in your state of residence to see if one is willing to approve the test. In almost every case, a licensed provider will approve the MTHFR genetic test for you and it generally happens within one hour or less. Assuming your MTHFR test is approved, you will need to take the lab order to your selected Quest Diagnostics lab and get your blood drawn. Once your MTHFR lab report is available, the ordering provider will review it and release it to you where the MTHFR results will be accessible in your Push Health account.

The MTHFR test is a genetic test and, like the celiac genetic test and the Factor V Leiden test, is not the type of traditional lab test that many medical providers order on a regular basis. Push Health is pleased to connect people with medical providers in their area to get MTHF gene mutation testing.